176 Evaluation of Meloxicam Plasma Concentrations Using a Microneedle Patch for Drug Delivery

Abstract To evaluate meloxicam plasma concentrations using a microneedle patch, 12 pigs (initial BW = 2.5 ± 0.53 kg) were stratified into of 4 treatment groups. Treatment groups were: 1) (n 2) received 0.5 mg/kg via oral drench (oral); patch with no (placebo); 3) 4) dosed at (low dose); and 2 patches 5 (high dose). Blood was collected for analysis 0, 2, 4, 8, 12, 24, 48, 72, 96, 168 hours. Microneedle adhered on the pinna ear after blood collection 0 hour. Statistical analyses performed MIXED procedure SAS 9.4, assessing effects treatment, time, × time interaction. significance determined P ≤ 0.05, tendencies 0.05 < ≥ 0.1. There interaction (P 0.0001), group having greater 8 hours than placebo, low dose, high dose but there differences > 0.1). The tended to have compared placebo 0.09), 0.054), 0.054) between any timepoint Meloxicam in detectable both (0.21 ng/mL) (1.14 ng/mL). Research is continuing determine ideal dosage needed deliver desired concentrations.